Outcome of urinary tract infection caused by Extended Spectrum Beta-Lactamase (ESBL) producing Escherichia coli and Klebsiella pneumoniae in Dr Zainoel Abidin General Hospital Aceh

Introduction : Extended-spectrum ?-lactamase (ESBL) is a mutated enzyme that can hydrolyze beta-lactam antibiotics. The aim of this study was to determine the incidence rate, characteristics patients, antibiotic use and outcome urinary tract infections (UTIs) due ESBL-producing Escherichia coli Klebsiella pneumoniae at Dr Zainoel Abidin General Hospital Aceh.Method samples were all isolated from urine culture UTI cases. Patient data extracted medical records. UTIs assessed as clinical improvement or death within maximum 30 days treatment.Result results obtained 63 patients with caused by E. K. pneumonia which 52.4% them ESBL producers. higher than pneumoniae, 63.5% 36.5% respectively. producers more in number non-ESBL, conversely mostly non-ESBL. predominant women 52.4%, most cases 56-64 years old. Antibiotic therapy given before after generally ceftriaxone. producing showed 26/33 (78.8%) experienced improvement, however, 7/33 (21.2%) died.Conclusion irrational ceftriaxone has led poor for patient.